Polypharmacological Constituents and Potential Activities of Bergenia ciliata: A Concise Review Natural Product Chemistry
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Abstract
Bergenia ciliata is an evergreen perennial herb belonging to the family Saxifragaceae and has been employed in traditional medicine since long. When compared to pharmaceutical medication, traditional herbal medicine is seen as the lifeline and the first option. Due to Bergenia ciliata's wide range of biological activity, several traditional uses have been documented. Investigations into the discovery of its phytocompounds, chemistry, pharmacology, and medicinal use of Bergenia plants have been conducted in recent years. It is reported to be beneficial in breaking up bladder and kidney stones, it also aids in the removal of blockages and hazardous waste products from alimentary canal and urinary system. Additionally, it relieves pain in the ribs and chest brought on by too much cold humour and is a great emmenagogue and diuretic. It also exhibits hepato & nephro-protective, antidiabetic, antioxidant, and bio prospective qualities. Bergenia ciliata when subjected to a polypharmacological composition screening, identified the presence of tannins, steroids, flavonoids, terpenoids, alkaloids, and saponins. Bergenia ciliata has a potential use in pharmacology and medicine because of the presence of plethora of polyphenols. The purpose of this article is to compile and evaluate the existing data about the phytochemistry and potential activities of Bergenia ciliata.
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A. Hussain, M. Kanth, P. K. Shrivastava, M. Sharma, J. Tripath, M. A. Khan. Phytochemical analysis of the rhizomes of Bergenia ciliata (Haw) Sternb. J. Drug Deliv Therap., 2019, 9, 412.
C. P. Bahu, R. T. Seshadri. Advances in research in “Indian Medicine”, “Pashanbedi” drugs for urinary calculus, Udupa K.N.(Eds)., 1970, 77.
L. Singh, A. Kumar, A. Paul. Bergenia ciliata: The medicinal herb of cold desert. Int. J. Chem. Sci., 2018, 6, 3609.
M. S. Bagul, M. Ravishankara, H. Padh, M. Rajani. Phytochemical evaluation and free radical scavenging properties of rhizome of Bergenia ciliata (Haw.) Sternb. forma ligulata Yeo. J. Nat. Remedies., 2003, 3, 83. https://doi.org/10.18311/jnr/2003/369
A. J. Grierson, D. G. Long. Flora of Bhutan: including a record of plants from Sikkim. Edinburgh: Royal Botanic Garden Edinburgh. 1983.
G. Y. Zuo, Z. Q. Li, L. R. Chen, L. R, X. J. Xu. in vitro anti-Hcv activities of Saxifraga melanocentra and its related polyphenolic compounds. Antiviral Chem. Chemoth., 2005, 16, 393. https://doi.org/10.1177/095632020501600606.
B. Joshi, S. Lekhak, A. Sharma. Antibacterial property of different medicinal plants: Ocimum sanctum, Cinnamomum zeylanicum, Xanthoxylum armatum and Origanum majorana. Kathmandu Univ. J Sci Eng Technol., 2009, 5, 143.: https://doi.org/10.3126/kuset.v5i1.2854
K. Krasniewska, M. Gniewosz, A. Synowiec, J. L. Przybyl, K. Baczek. the application of pullulan coating enriched with extracts from Bergenia crassifolia to control the growth of food microorganisms and improve the quality of peppers and apples. FBP., 2014, https://doi.org/10.1016/j.fbp.2014.06.001
D. P. Singh, S. K. Srivastava, R. Govindarajan, A. K. S. Rawat. High performance liquid chromatographic determination of bergenin in different Bergenia species. Acta Chromatogr., 2007, 19, 246.
N. Khan, A. M. Abbasi, G. Dastagir, A. Nazir, G. M. Shah, M.M. Shah, M.H. Shah. Ethnobotanical and antimicrobial study of some selected medicinal plants used in Khyber Pakhtunkhwa (KPK) as a potential source to cure infectious diseases. BMC Complement. Altern. Med., 2014, 14, 122. https://doi.org/10.1186/1472-6882-14-122
R. Zhang, K. Eggleston, V. Rotimi, R. J. Zeckhauser. Antibiotic resistance as a global threat: evidence from China, Kuwait and the United States, Glob. Health., 2006, 2, 6. https://doi.org/10.1186/1744-8603-2-6
C. Das, B. Kumari, M. P. Singh, S. Singh. A Literary Review and Therapeutic Action of Pashanbheda (Bergenia ligulata Wall.) described by Shamita in Ashmari Roga. J. Ayurveda Integ. Med. Sci., 2022, 7, 105-114. https://jaims.in/jaims/article/view/1861.
K. Ruby, R. Chauhan, S. Sharma, J. Dwivedi. Polypharmacological activities of Bergenia species, Int. J. Pharm. Pharm. Sci., 2012, 1, 100.
K. Mishra, L. Ganju, M. Sairam, P. Banerjee, R. Sawhney. A review of high throughput technology for the screening of natural products, Biomed. Pharmacother., 2008, 62, 94. https://doi.org/10.1016/j.biopha.2007.06.012.
P. Chase, O. Singh. Ethnomedicinal plants used by angami tribe of Nagaland, India. Indian J. Trop. Biodivers., 2013, 21, 29.
P. M. Shrestha, S. S. Dhillion. Medicinal plant diversity and use in the highlands of Dolakha district Nepal, J. Ethnopharmacol., 2003, 86, 81. https://doi.org/10.1016/s0378-8741(03)00051-5
S. Karki, S. Chowdhury, S. Nath, K. C. Dora, P. Murmu. Phytochemistry and ethnomedicinal use of Bergenia species-a miraculous herb. Indian J. Anim Health., 2021, 60,143
J. L. Yuan, J. L. Suo. Research progress in medicinal plant genu Bergenia Moench. J. Baoji Univ. Arts Sci. Nat. Sci., 2011, 31, 46.
N. Singh, V. Juya, A. K. Gupta, M. Gahlot. Evaluation of ethanolic extract of root of Bergenia ligulata for hepatoprotective, diuretic and antipyretic activities. J. Pharm. Res., 2009, 2, 958.
P. Shrestha, S. Adhikari, B. Lamichhane, B. G. Shrestha. Phytochemical screening of the medicinal plants of Nepal. IOSR J. Environ. Sci. Toxicol. Food Technol., 2015, 11–17
M. Yuldashev, È. K. Batirov, V. Malikov. Anthraquinones of Bergenia hissarica. Chem. Nat. Compd., 1993, 29, 543. https://doi.org/10.1007/BF00630591
R. A. Moreau, B. D. Whitaker, K. B. Hicks. Phytosterols, phytostanols, and their conjugates in foods: structural diversity, quantitative analysis, and health-promoting uses. Prog. Lipid Res., 2002, 41, 457. DOI: https://doi.org/10.1016/s0163-7827(02)00006-1
A. Yaginuma, K. Murata, H. Matsuda. Beta-glucan and Bergenia ligulata as cosmetics ingredient. Fragrance J. 2003, 31, 114. DOI: https://doi.org/10.22270/jddt.v9i3.2687
R. Árok, K. Végh, Á. Alberti, Á. Kéry. Phytochemical comparison and analysis of Bergenia crassifolia l.(fritsch.) and Bergenia cordifolia sternb. Eur. Chem. Bull. 2012, 1, 31.
B. Patwardhan, A. Vaidya, M. Chorghade, S. Joshi. Reverse pharmacology and systems approach for drug discovery and development. Curr. Bioact. Compd., 2008, 4, 201. DOI: https://doi.org/10.2174/157340708786847870.
K. Satyavani, S. Gurudeeban, V. Manigandan, E. Rajamanickam, T. Ramanathan. Chemical compositions of medicinal mangrove species Acanthus ilicifolius, Excoecaria agallocha, Rhizophora apiculata and Rhizophora mucronata. Curr. Res. Chem., 2015, 7, 1. https://doi.org/10.3923/crc.2015.1.8
L. K. Han, H. Ninomiya, M. Taniguchi, K. Baba, Y. Kimura, H. Okuda. Norepinephrine Augmenting Lipolytic Effectors from Astilbe t hunbergii Rhizomes, J. Nat. Prod. 1998, 61, 1006. https://doi.org/10.1021/np980107o
N. Moktan, A. Banerjee. Polyphenol oxidases: challenges and future prospects. De Gruyter., 2024, 293. https://doi.org/10.1515/9783111033525-011
S. Chowdharya, H. Kumar, K. Verma. Quantitative Assessment of Current Status and Biomass of Bergenia ciliata and Bergenia stracheyi from Kumaun Himalaya, International Journal of Applied Biology and P., 2010, 360.
M. Roselli, G. Lentini, S. Habtemariam. Phytochemical, antioxidant and anti-α-glucosidase activity evaluations of Bergenia cordifolia, Phytother. Res., 2012, 26, 908.
A. Kumar, M. Mitra, B. Adhikari, G. S. Rawat. Depleting indigenous knowledge of medicinal plants in cold-arid region of Nanda Devi Biosphere Reserve, Western Himalaya. Med. Aromat. Plants., 2015, 4, 2167.: https://doi.org/10.4172/2167-0412.1000195
M. Ahmad, M. A. Butt, G. Zhang, S. Sultana, A. Tariq, M. Zafar. Bergenia ciliata: A comprehensive review of its traditional uses, phytochemistry, pharmacology and safety. Biomedicine & Pharmacotherapy., 2018, 97, 708. https://doi.org/10.1016/j.biopha.2017.10.141
M. R. Bhandari, N. Jong-Anurakkun, G. Hong, J. Kawabata. α-Glucosidase and α-amylase inhibitory activities of Nepalese medicinal herb Pakhanbhed (Bergenia ciliata, Haw.), Food Chem., 2008, 106, 247. https://doi.org/10.1016/j.foodchem.2007.05.077
B. K. Sapkota, K. Khadayat, K. Sharma, B. K. Raut, D. Aryal, B. B. Thapa, N. Parajuli. Phytochemical Analysis and Antioxidant and Antidiabetic Activities of Extracts from Bergenia ciliata, Mimosa pudica, and Phyllanthus emblica. Adv. Pharmacol. Pharma. Sci., 2022, 5, 4929824. https://doi.org/10.1155/2022/4929824
P. C. Santos-Gomes, M. Fernandes-Ferreira. Organ-and season-dependent variation in the essential oil composition of Salvia officinalis L. cultivated at two differentsites, J. Agric. Food Chem., 2001, 49, 2908. https://doi.org/10.1021/jf001102b
S. Roychoudhury, D. Das, S. Das, N. K. Jha, M. Pal, A. Kolesarova, K. K. Kesari, J. C. Kalita, P. Slama. Clinical Potential of Himalayan Herb Bergenia ligulata: Evidence Based Study. Molecules, 2022., 27, 7039. https://doi.org/10.3390/molecules27207039
R. Venkatadri, G. Guha, A. K. Rangasamy. Anti-neoplastic activity of Bergenia ciliata rhizome. J. Pharm. Res., 2011, 4, 44
I. Azhar, K. Usmanghani, M. A. Gill, A. Ahmad, A. Ahmad. Antifungal activity evaluation of Bergenia ciliata. Pak J Pharm Sci., 2002, 19, 1.
K. Dhalwal, V. M. Shinde, Y. S. Biradar, K. R. Mahadik. Simultaneous quantification of bergenin, catechin, and gallic acid from Bergenia ciliata and Bergenia ligulata by using thin-layer chromatography. J. Food Composit. Anal., 2008, 21, 496. https://doi.org/10.4172/2153-2435.1000104
M. Rajbhandari, U. Wegner, T. Schoepke, U. Lindequist, R. Mentel. Inhibitory effect of Bergenia ligulata on influenza virus A. Int. J. Pharm. Sci. 2003, 58, 268.
N. N. Azwanida. A review on the extraction methods uses in medicinal plants, principle, strength and limitation. Med. Aromat. Plants., 2015, 4, 196. https://dx.doi.org/10.4172/2167-0412.1000196
P. Carmen, L. Vlase, M. Tamas. Natural resources containing arbutin. Determination of arbutin in the leaves of Bergenia crassifolia (L.) Fritsch. Acclimated in Romania. Notulae Botanicae Horti Agrobotanici Cluj-Napoca., 2009, 37, 129. https://doi.org/10.15835/nbha3713108
R. Chauhan, K. Ruby, J. Dwivedi. Bergenia ciliata mine of medicinal properties: A Review. Int. J. Pharm. Sci. Rev. Res., 2012, 15, 20.
S. A. Gilani, R. A. Qureshi, S. J. Gilani. Indigenous uses of some important ethnomedicinal herbs of Ayubia National Park, Abbottabad, Pakistan, Ethnobot. Leafl., 2006, 1, 32.
S. S. Shah, A. Dawood, K. Ibrahim, I. Muhammad, A. J. Sohail. Bergenia ciliata as antibacterial agent. GSC Bio. Pharma. Sci., 2020, 12, 37
R. Gyawali. Phytochemical screening and anti-microbial properties of medicinal plants of Dhunkharka community, Kavrepalanchowk, Nepal. Int. J. Pharm. Biol. Arch., 2011, 2
R. Gyawali, K. S. Kim. Bioactive volatile compounds of three medicinal plants from Nepal. Kathmandu University J. Sci. Eng. Technol., 2011, 8, 51. https://doi.org/10.3126/kuset.v8i1.6043
M. Khan, M. A. Khan, G. Mujtaba, M. Hussain. Ethnobotanical study about medicinal plants of Poonch valley Azad Kashmir. J. Anim. Plant Sci., 2012, 22, 493. https://api.semanticscholar.org/CorpusID:27813371
N. Kushwana, A. Singh. Bergenia ciliata-Phytochemistry and Pharmacology: A review. J. Biomed Mat & amp., 2024, 2, 891. https://doi.org/10.1007/s44174-024-00156-6
M. Hasan, P. Gatto, P. Jha. Traditional uses of wild medicinal plants and their management practices in Nepal—a study in Makawanpur district. Int. J. Med. Aromat. Plants., 2013, 3, 102.
V. V. Byahatti, K. V. Pai, M. G. Dsouza. Effect of phenolic compounds from Bergenia ciliata (Haw.) Sternb.leaves on experimental kidney stones. Ancient Sci. Life., 2010, 30, 14.
V. Chahar, B. Sharma, G. Shukla, A. Srivastava. A. Bhatnagar. Study of Antimicrobial Activity of Silver Nanoparticles Synthesized Using Green and Chemical Approach. Colloids Surf. A Physicochem. Eng. Asp., 2018, 554, 149.
E. Ali, N. Arshad, N. I. Bukhari, M. N. Tahir, S. Zafar, A. Hussain, S. Praveen, S. Qamar, N. Shehzadi, K. Hussain. Linking traditional anti-cancer use of rhizomes of Bergenia ciliata (Haw.) Sternb. to its anti-Helicobacter pylori constituents. Nat. Prod. Res., 2020, 34, 541. https://doi.org/10.1080/14786419.2018.1488711.
N. P. Manandhar. Medicinal folklore about the plants used as anthelminthic agents in Nepal. Fitoterapia., 1995, 66, 149.
R. Verma, A. Tapwal, D. Kumar, S. Puri. Assessment of Antimicrobial Potential and Phytochemical Profiling of Ethnomedicine Plant Bergenia ciliata (Haw.) Sternb. In Western Himalaya. J. Micro. Biotech. Food Sci., 2019, 9,15. https://doi.org/10.15414/jmbfs.2019.9.1.15-20.
Y. Subba, S. Hazra, C. H. Rahaman. Medicinal plants of Teesta Valley, Darjeeling district, West Bengal, India: A quantitative ethnomedicinal study. J. App. Pharma. Sci., 2023, 13, 93. https://doi.org/10.7324/JAPS.2023.130109
P. Pokhrel, R. R. Parajuli, A. K. Tiwari, J. Banerjee. A short glimpse on promising pharmacological effects of Bergenia ciliata. JOAPR., 2014, 2, 1.
V. Kumar, D. Tyagi. Review on phytochemical, ethnomedical and biological studies of medically useful genus Bergenia. Int J Curr Microbiol App Sci., 2015, 2, 328.
M. Stuffness, J. M. Pezzuto. Assay related to cancer drug discovery. In Hostettmann K.(ed). Methods in plant biochemistry. Assays for Bioactivity, 6. Academic press-London. 1990, 71-133.
M. Y. Khan, V. Kumar. Phytopharmacological and Chemical Profile of Bergenia ciliata. Intern.J. Phytopharmacy., 2016, 6, 90.
R. Hafidh, A. Abdulamir, F. Jahanshiri, F. Abas, F. Abu Bakar, Z. Sekawi. Asia is the mine of natural antiviral products for public health. Open Complement Med. J., 2009, 1, 58.
H. Khan. Medicinal plants in light of history: Recognized therapeutic modality. J. Evid. Based Integr. Med., 2014, 19, 216. https://doi.org/ 10.1177/2156587214533346.
S. V. Tsyrenrzhieva, I. V. Khamaganova. The use of black leaves of Bergenia in food production. Food Processing: Techniques and Technology., 2017, 2, 81-86. https://naukaru.ru/en/nauka/article/27170/view
C. Smith-Hall, H. O. Larsen, M. Pouliot. People, plants and health: a conceptual framework for assessing changes in medicinal plant consumption. J Ethnobiol Ethnomed., 2012, 8, 43. https://doi.org/10.1186/1746-4269-8-43.
M. G. Castejón, A. R. Casado. Dietary phytochemicals and their potential effects on obesity: a review, Pharmacol. Res., 2011, 64, 438. https://doi.org/10.1016/j.phrs.2011.07.004
M. Rajbhandari, R. Mentel, P. K. Jha, R. P. Chaudhary, S. Bhattarai, M. B. Gewali, N. Karmacharya, M. Hipper, U. Lindequist. Antiviral activity of some plants used in Nepalese traditional medicine. Evidence-Based Comple. Altern. Med., 2007, 6, 517. https://doi.org/10.1093/ecam/nem156
M. Islam, I. Azhar, K. Usmanghani, M. Aslam, A. Ahmad. Bioactivity evaluation of Bergenia ciliata. Pak. J. Pharm.Sci., 2002, 15, 15. https://doi.org/ 10.1002/ptr.3655
X. Yang, Z. Wang, Wang, R. Li. Analysis of nutritive components and mineral element of Bergenae pacumbis in Tibet. J. Chang. Veg., 2009, 22, 57.
S. Rehman, Z. Iqbal, R. Qureshi, T. S. AlOmar, N. Almasoud, M. Younas, A. Rauf, M. Irfan. Ethno Dentistry of Medicinal Plants Used in North Waziristan, Pakistan. International Dental Journal., 2024, 74, 310. https://doi.org/10.1016/j.identj.2023.10.001
K. Ahn. The worldwide trend of using botanical drugs and strategies for developing global drugs. BMB Reports., 2017, 50, 111. https://doi.org/10.5483/BMBRep.2017.50.3.221
S. Gurav, N, Gurav. A comprehensive review: Bergenia ligulata wall-a controversial clinical candidate. Int. J. Pharm. Sci. Rev. Res., 2014, 5, 1630. https://doi.org/10.13040/IJPSR.09758232.5(5).1630-42
H. Kour, R. Rana, P. K. Verma, N. K. Pankaj, S. P. Singh. Phytochemical ingredients and pharmacological properties of Bergenia ciliata. Journal Of Veterinary Pharmacology and Toxicology., 2019, 18, 1
R. M. Kunwar, L. Mahat, R. P. Acharya, R. W. Bussmann. Medicinal plants, traditional medicine, markets and management in far-west Nepal. J. Ethnobiol. Ethnomed., 2013, 9, 24. https://doi.org/10.1186/1746-4269-9-24
V. Manandhar, G. Guha, R. A. Kumar. Anti-neoplastic activities of Bergenia ciliata rhizome, J. Pharm. Res., 2011, 4, 443.
G. Uddin, A. Rauf, M. Arfan, M. Ali, M. Qaisar, M. Saadiq, M. Atif. Preliminary phytochemical screening and antioxidant activity of Bergenia ciliata. Middle-East J. Sci. Res., 2012, 11, 1140.