Emerging Trends and Recent Development in the Synthesis of Non-Viral Cationic Systems for Targeted Gene Delivery Applications Polymer Science

Main Article Content

Sivaranjani Elumalai
Lavanya Jujjuri
Anubhab Das
Varsha K P
Prof. Samarendra Maji

Abstract

The development of a safe and efficient nucleic acid delivery system remains a major challenge in gene therapy. Viral and non-viral vectors are widely explored: Viral vectors often achieve high transduction efficiency, but are limited by high immunogenicity, oncogenic risk, and complex production processes, whereas non-viral vectors are comparatively safer, easily scalable, and structurally versatile; however, their clinical application is limited by low transfection efficiency. To overcome these challenges, hybrid strategies that combine different non-viral systems have emerged as a prominent approach for safer therapeutic gene delivery. Among these systems, lipid-based and polymer-based cationic systems have been extensively explored due to their tunable chemical structures and high nucleic acid loading capacity, enabling the design of multifunctional cationic systems for efficient and safe delivery. Hence, this review focuses on the synthesis and design of multifunctional cationic systems, highlighting their potential to overcome current barriers in non-viral gene delivery and to advance next-generation therapeutic platforms.

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How to Cite
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Emerging Trends and Recent Development in the Synthesis of Non-Viral Cationic Systems for Targeted Gene Delivery Applications: Polymer Science. Innov. Chem. Mater. Sustain. 2026, 3 (1), 29-54. https://doi.org/10.63654/icms.2026.03029.
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Review Article
Author Biographies

Sivaranjani Elumalai, Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology (SRMIST), Kattankulathur, Tamil Nadu 603203, India.

Ms. Sivaranjani Elumalai was born and raised in Chennai, Tamil Nadu, India. She received her Bachelor of Science in Chemistry (2022) from Anna Adarsh College for Women, Chennai. She subsequently completed her Master’s degree in Chemistry (2024) from B. S. Abdur Rahman Crescent Institute of Science and Technology, Chennai. She is currently pursuing her Ph.D. under the guidance of Dr. Samarendra Maji at SRM Institute of Science and Technology, Kattankulathur Campus, Chennai. Her research focuses on the design and synthesis of lipid-based cationic polymers for gene delivery applications.

Lavanya Jujjuri, Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology (SRMIST), Kattankulathur, Tamil Nadu-603203, India.

Ms. Lavanya Jujjuri was born and raised in Andhra Pradesh, India. She received her B.Sc. in Chemistry (2021) from Acharya Nagarjuna University, Guntur, Andhra Pradesh. She completed her Master’s degree in Chemistry (2023) from GITAM School of Sciences, Visakhapatnam, Andhra Pradesh. She is currently pursuing her Ph.D. at SRM Institute of Science and Technology, Kattankulathur (KTR), Chennai under the guidance of Dr. Samarendra Maji. Her research focuses on the design and synthesis of degradable polymers for drug delivery application.

Anubhab Das, Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology (SRMIST), Kattankulathur, Tamil Nadu-603203, India.

Mr. Anubhab Das was born and raised in Kakdwip, West Bengal, India. He received his B.Sc. in Chemistry (2017) from Dinabandhu Andrews College, Kolkata in West Bengal. He completed his Master's in Chemistry (2019) from Scottish Church College, Kolkata in West Bengal. He is currently pursuing his Ph.D. under the guidance of Dr. Samarendra Maji from SRM Institute of Science and Technology, Kattankulathur Campus, Chennai, Tamilnadu. His research has focused on the development of novel smart polymeric materials that may be utilized to identify nitrogenous contaminants in agricultural samples.

Varsha K P, Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology (SRMIST), Kattankulathur, Tamil Nadu-603203, India.

Ms. Varsha K P is currently pursuing her Ph.D at the SRM Institute of Science and Technology, Kattankulathur, Chennai, under the guidance of Dr. Samarendra Maji. She has awarded her Masters (2024) and Bachelors (2020) degree from University of Calicut, Kerala. Her research focuses on the development of novel nanocomposites for the removal of heavy metals from aqueous systems.

Prof. Samarendra Maji, Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology (SRMIST), Kattankulathur, Tamil Nadu-603203, India.

Dr. Samarendra Maji obtained his M.Sc. degree in Chemistry (Organic) from Banaras Hindu University, Varanasi, in 2004 and obtained his M. Tech. degree in Materials Science and Engineering in 2006. He obtained a Ph. D. from Indian Institute of Technology, Kharagpur, under the supervision of Prof. Susanta Banerjee in 2010 and performed postdoctoral research with Prof. Andreas Greiner & Prof. Seema Agarwal (Philipps University Marburg, Germany) and Prof. Richard Hoogenboom (Ghent University, Belgium). Currently, he is working as Research Associate Professor, in the Department of Chemistry, SRM Institute of Science and Technology (SRMIST), Kattankulathur. His major research interests are Synthesis of polymers via CRP’s (RAFT/MADIX), Stimuli responsive polymers & Polymeric-inorganic hybrid nanomaterials. He is the recipient of prestigious Alexander von Humboldt Fellowship of Germany (2010) and FWO Pegasus Marie Curie Fellowship of Belgium (2012).

How to Cite

(1)
Emerging Trends and Recent Development in the Synthesis of Non-Viral Cationic Systems for Targeted Gene Delivery Applications: Polymer Science. Innov. Chem. Mater. Sustain. 2026, 3 (1), 29-54. https://doi.org/10.63654/icms.2026.03029.

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